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, there was a tense disagreement about which ball to use. So for the final game of this famous 1930 competition, FIFA intervened and Argentina got to use their “Tiento” for the first half while Uruguay put in a “T-model” for the second:

For decades, each subsequent competition saw an evolution in ball design. Still, most held to a similar format made up of parallel and perpendicular leather strips — that is, until the iconic Telstar ball hit the field during a crucial period of change for at-home sports viewing.

In 1970, the United States was in the middle of transitioning to color televisions. Most households had TVs, but the majority of those were still black-and-white sets. So the new ball design featured a high-contrast array of black pentagons alternating with white hexagons.

This pattern made the ball’s form and motion clearer both on the field and on home screens, a big improvement on the uniform organic colors of earlier balls. The new look also informed that year’s event logo, with its dark geometric shapes against a light background (designed by Dolce amp; Gabbana Tall Boot Cyp6ndP
).

Developed by Adidas, the Telstarwas the first World Cup ball to use the now-familiar Skechers GOwalk Evolution Ultra Turbo Walking Shoe Womens zpvWgvZhNs
for its design, consisting of 12 black pentagonal and 20 white hexagonal panels. It has since become the world’s most recognizable soccer(or: football) ball.

Following the designs’ success, the same company has been designing World Cup balls ever since. They have continued to change, but the basic idea of using alternating tone patterns is often used to help players and onlookers alike keep better track of the action.

Side note: one could be forgiven for accepting at face value a widely-circulated claim that Buckminster Fuller designed the modern soccer ball (a claim repeated in this otherwise neat ball history video):

Though he widely used triangles to create his Converse Chuck Taylor All Star Double Tongue Sneaker Women Dapup
, theBuckminsterfullerene (or “ Stu Avery Hurrache Leather Sandal EyozXR
“) shape named after this famous architect does strongly resemble a soccer ball. There is, however, no evidence that he was involved in the design.

In fact, the ball was named after (and looks like) a key communications satellite launched in 1962. Aportmanteau of “television” and “star,” this original French Connection Quincy BEs3VKsS
transmitted the first live transatlantic TV feed (as well as the first telephone and fix signals) through space.

Color and shape also aren’t the only things that set the Telstar and other newer balls apart. Made out of animal bladders and stomachs, many early soccer balls naturally broke down with use. Other old variants employed cork shavings inside a leather shell, but hitting a wet leather ball (particularly with one’s head) can be dangerous and painful. In the 1800s, innovations in rubber vulcanization led to sturdier new models. In more recent years, the use of thermal bonding has helped balls become more spherical and easier to handle as well.

When DENV 2-infected patients were considered individually, 3 DENV 2/IgG + patients (2056, 2287, and 2425) had viral loads (1 × 10 8 to 1 × 10 9 genomic equivalent/mL) that were up to 2 logs higher than the other patients. This might represent the antibody-dependent enhancement (ADE) of DENV viral load, despite the fact that only 1 of these patients had severe manifestations of dengue (Supplementary Table 2).

There was also no significant difference in viral load between the DENV IgG + and IgG patients infected by ZIKV (n = 44; P = .25, Mann-Whitney U test). The least significant value for this analysis was 0.70 log 10 PFU/mL; thus, the analysis had high power (90%) to detect a 10-fold difference in viral load between IgG + and IgG patients. Moreover, no IgG + patients had dramatically higher levels of ZIKV than the IgG patients ( Figure 1 ).

Figure 1.
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Viral load in patients with Zika virus (ZIKV) and dengue virus (DENV) serotype 2 during primary and secondary dengue infections. , Viral load quantified in ZIKV-positive patients with primary (immunoglobulin G–negative [IgG]) DENV infection (n = 10) and secondary (immunoglobulin G–positive [IgG]) DENV infection (n = 35). The Mann-Whitney test demonstrated no significant difference in viral load. , Viral load quantified in DENV 2 patients with primary (IgG) DENV infection (n = 6) and secondary (IgG) DENV infection (n = 14). The Mann-Whitney test demonstrated no significant difference in viral load. Medians with interquartile range are shown.

Figure 1.
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Viral load in patients with Zika virus (ZIKV) and dengue virus (DENV) serotype 2 during primary and secondary dengue infections. , Viral load quantified in ZIKV-positive patients with primary (immunoglobulin G–negative [IgG]) DENV infection (n = 10) and secondary (immunoglobulin G–positive [IgG]) DENV infection (n = 35). The Mann-Whitney test demonstrated no significant difference in viral load. , Viral load quantified in DENV 2 patients with primary (IgG) DENV infection (n = 6) and secondary (IgG) DENV infection (n = 14). The Mann-Whitney test demonstrated no significant difference in viral load. Medians with interquartile range are shown.

A commercial panel consisting of IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-9, IL-10, IL-13, and IL-17 was used to analyze the levels of circulating cytokines in patients exposed to a second infection. These cytokines are involved in the “cytokine storm” phenomenon that is known to affect patients with severe dengue and which may be considered a marker of severe disease [ 7 ] (Supplementary Table 2).

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